Anna Krichevsky, PhD

Assistant Professor of Neurology at Harvard Medical School, Boston, MA. Dr. Krichevsky is also a Principal Investigator at the Center for Neurologic Diseases, Department of Neurology, Brigham & Women’s Hospital.

Education:

• PhD in Molecular and Cellular Biology from Hebrew University of Jerusalem, Israel

Fellowships:

• Postdoctoral training in Neurobiology, Brigham & Women’s Hospital and Harvard Medical School, Boston, MA

Research Interests:

The major goal of Dr. Krichevsky’s work centers on developing and validating a novel microRNA-based approach for targeting glioblastoma and other neoplastic and neurologic brain disorders. As a postdoctoral fellow, she was involved in the work that led to recognition of microRNA functions in brain physiology and pathology.

Some of Dr. Krichevsky’s accomplishments include: performing the first successful RNA interference in mammalian neurons (Krichevsky et al., PNAS 2002); contributing to identification of microRNAs in mammalian brain (Kim et al., PNAS 2004); developing the first high-throughput arrays for microRNA expression profiling (Krichevsky et al., RNA 2003); and identifying the first oncogenic microRNA, miR-21, in gliomas (Chan et al., Cancer Res 2005). More recently, Dr. Krichevsky’s laboratory has worked on identification and studying key microRNAs involved in human brain tumors (Gabriely et al., Mol Cell Biol 2008; Wurdinger et al., Cancer Cell 2008; Krichevsky and Gabriely, JCMM 2009; Gabriely et al., Cancer Res 2011) and neurodegenerative disorders (Ponomarev et al., Nature Medicine 2011).

Current research builds logically on previous work and experience with microRNA, neural, glioma, and stem cells, and further extends it to establish a microRNA-based therapy for glioblastoma.