The BSF is proud to support a new set of clinical initiatives that hold great promise in the area of Meningioma treatment. Using BSF funds, investigators: Priscilla Brastianos, MD; Ian Dunn, MD; Sandro Santagata, MD, PhD; and Rameen Beroukhim, MD, PhD discovered novel recurrent mutations in Meningiomas that will have significant impact on the future treatment of these tumors. These mutations are known genetic targets in other cancer types but had never been described in Meningiomas until now. Dr. Brastianos has launched a far reaching, multi-institutional Phase II Study looking at inhibitors that target these mutations. This is the first ever trial of personalized drug therapies for Meningiomas, and represents a paradigm shift in Meningioma therapy!

To learn more about these trials, please click here to read the official NIH posting or visit brastianoslab.mgh.harvard.edu/. Patients who are interested in enrolling should share the NIH posting with their treating oncologist to determine eligibility.

The Brain Science Foundation is proud to support this groundbreaking study, and we hope our advocates will join us in supporting this work with your financial contribution to our Annual Appeal. Click here to make your secure, tax deductible contribution, or checks may be mailed to Brain Science Foundation, PO BOX 812701, Wellesley, MA 02482.

The first immunotherapy trial to investigate the role of immune checkpoint blockade for meningioma tumors is currently underway. Our group at the Dana-Farber Cancer Institute/Brigham and Women’s Hospital studied a number of meningioma tumors and noted that most grade 2 and 3 meningiomas, and some grade 1 meningiomas, express a molecule called PD-L1 (programmed death ligand 1). PD-L1 and its binding partner PD-1 have been shown to be critical molecules expressed by many cancers that function to protect the tumor from being attacked by the immune system. Blocking PD-1 has led to dramatic improvements in survival for patients with a wide variety of cancers. We therefore initiated a phase II study of nivolumab (also known as Opdivo) which is a PD-1 inhibitor for patients with grade 2 or 3 meningiomas that have progressed after prior radiation and surgery.

The trial is enrolling patients to participate. Nivolumab is provided free of charge and is administered every two weeks as a 30 minute infusion in the Dana-Farber clinic. The treatment continues as long as it is working. Side effects have been minimal and although not all patients are responding, preliminary results are encouraging. If you have further questions about the trial please get further information at clinicaltrials.gov (NCT02648997), or contact the Center for Neuro-Oncology at the Dana-Farber Cancer Institute (617-632-4750) or visit the Dana-Farber Center for Neuro-Oncology website (www.dana-farber.org).

David A. Reardon, MD
Professor of Medicine, Harvard Medical School
Clinical Director, Center for Neuro-Oncology
Dana-Farber Cancer Institute
450 Brookline Avenue, D2134
Boston, MA 02215-5450
Telephone: 617-632-2356
Facsimile: 617-632-4773
Email: david_reardon@dfci.harvard.edu.

Administrative Assistant: Patrick Curran
Telephone: 617-632-4750
Facsimile: 617-632-4773
Email: patrickj_curran@dfci.harvard.edu.