The Role of the cdc20-Anaphase Promoting Complex Signaling Pathway in Cerebellar Granule Cell Precursor Development and Medulloblastoma Migration

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Dr. Albert Kim, MD, PhD
*Funded in collaboration with the Daniel E. Ponton Fund for the Neurosciences at Brigham and Women’s Hospital

Primary brain tumors are the most common solid tumors in children. Among these tumors, medulloblastoma is the most commonly diagnosed, with a startlingly low five-year survival rate, despite current treatments. In order to give these young patients a brighter future, Dr. Albert Kim is studying the role of a specific central nervous system cell in the mechanisms leading to the development of medulloblastoma.

By better understanding the inner workings of these cells, Dr. Kim hopes to create precisely targeted treatments that will stop the tumor growth at its source, and give children a leg up in the fight against brain cancer.